exploring the biological contributions to human health: does sex matter Search Results


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Chem Impex International sodium fluoride
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Binding mode of favipiravir to the <t>SARS-CoV-2</t> and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.
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MatTek epioral tissues
Binding mode of favipiravir to the <t>SARS-CoV-2</t> and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.
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MatTek reconstructed human epidermis (rhe) model epidermtm
Binding mode of favipiravir to the <t>SARS-CoV-2</t> and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.
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MatTek human skin tissue epiderm-fttm model
Binding mode of favipiravir to the <t>SARS-CoV-2</t> and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.
Human Skin Tissue Epiderm Fttm Model, supplied by MatTek, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Binding mode of favipiravir to the SARS-CoV-2 and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.

Journal: Scientific Reports

Article Title: Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models

doi: 10.1038/s41598-021-02972-y

Figure Lengend Snippet: Binding mode of favipiravir to the SARS-CoV-2 and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.

Article Snippet: Since no specific treatment is available, this study aims to explore the anti-SARS-CoV-2 agents including favipiravir and remdesivir for treating HCoV-NL63 infection.

Techniques: Binding Assay

Binding mode of remdesivir to the SARS-CoV-2 and HCoV-NL63 RdRp. ( A ) Remdesivir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of remdesivir (atom color sticks) and the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and remdesivir. ( D ) Remdesivir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of remdesivir (atom color sticks) and the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and remdesivir.

Journal: Scientific Reports

Article Title: Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models

doi: 10.1038/s41598-021-02972-y

Figure Lengend Snippet: Binding mode of remdesivir to the SARS-CoV-2 and HCoV-NL63 RdRp. ( A ) Remdesivir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of remdesivir (atom color sticks) and the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and remdesivir. ( D ) Remdesivir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of remdesivir (atom color sticks) and the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and remdesivir.

Article Snippet: Since no specific treatment is available, this study aims to explore the anti-SARS-CoV-2 agents including favipiravir and remdesivir for treating HCoV-NL63 infection.

Techniques: Binding Assay

The root-mean-square deviations (RMSDs) of the backbone atoms and its ligands complex relative to their coordinates as a function of simulation time. ( A ) The average RMSDs of SARS-CoV-2 RdRp backbone atoms (Blue line) and its complexes with favipiravir (Green Line) or remdesivir (Red line) were plotted against the total simulation time. ( B ) The average RMSDs of HCoV-NL63 RdRp backbone atoms (Blue line) and its complexes with favipiravir (Green Line) or remdesivir (Red line) were plotted against the total simulation time.

Journal: Scientific Reports

Article Title: Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models

doi: 10.1038/s41598-021-02972-y

Figure Lengend Snippet: The root-mean-square deviations (RMSDs) of the backbone atoms and its ligands complex relative to their coordinates as a function of simulation time. ( A ) The average RMSDs of SARS-CoV-2 RdRp backbone atoms (Blue line) and its complexes with favipiravir (Green Line) or remdesivir (Red line) were plotted against the total simulation time. ( B ) The average RMSDs of HCoV-NL63 RdRp backbone atoms (Blue line) and its complexes with favipiravir (Green Line) or remdesivir (Red line) were plotted against the total simulation time.

Article Snippet: Since no specific treatment is available, this study aims to explore the anti-SARS-CoV-2 agents including favipiravir and remdesivir for treating HCoV-NL63 infection.

Techniques: