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MatTek
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SAS institute
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Image Search Results
Journal: Scientific Reports
Article Title: Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models
doi: 10.1038/s41598-021-02972-y
Figure Lengend Snippet: Binding mode of favipiravir to the SARS-CoV-2 and HCoV-NL63 RdRp. ( A ) Favipiravir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of favipiravir (atom color sticks) with the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and favipiravir. ( D ) Favipiravir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of favipiravir (atom color sticks) with the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and favipiravir.
Article Snippet: Since no specific treatment is available, this study aims to explore the
Techniques: Binding Assay
Journal: Scientific Reports
Article Title: Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models
doi: 10.1038/s41598-021-02972-y
Figure Lengend Snippet: Binding mode of remdesivir to the SARS-CoV-2 and HCoV-NL63 RdRp. ( A ) Remdesivir, bound to the SARS-CoV-2 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( B ) Molecular interactions of remdesivir (atom color sticks) and the SARS-CoV-2 RdRp residues (yellow sticks). ( C ) 2D diagram of interactions between SARS-CoV-2 RdRp and remdesivir. ( D ) Remdesivir, bound to the HCoV-NL63 RdRp (atom color ribbons) binding site, was depicted as surface representation with H-bond donor (purple) and acceptor (green). ( E ) Molecular interactions of remdesivir (atom color sticks) and the HCoV-NL63 RdRp residues (yellow sticks). ( F ) 2D diagram of interactions between HCoV-NL63 RdRp and remdesivir.
Article Snippet: Since no specific treatment is available, this study aims to explore the
Techniques: Binding Assay
Journal: Scientific Reports
Article Title: Comparative assessment of favipiravir and remdesivir against human coronavirus NL63 in molecular docking and cell culture models
doi: 10.1038/s41598-021-02972-y
Figure Lengend Snippet: The root-mean-square deviations (RMSDs) of the backbone atoms and its ligands complex relative to their coordinates as a function of simulation time. ( A ) The average RMSDs of SARS-CoV-2 RdRp backbone atoms (Blue line) and its complexes with favipiravir (Green Line) or remdesivir (Red line) were plotted against the total simulation time. ( B ) The average RMSDs of HCoV-NL63 RdRp backbone atoms (Blue line) and its complexes with favipiravir (Green Line) or remdesivir (Red line) were plotted against the total simulation time.
Article Snippet: Since no specific treatment is available, this study aims to explore the
Techniques: